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KMID : 0360419940300010075
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Korean Journal of Pharmacology
1994 Volume.30 No. 1 p.75 ~ p.86
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Regulatory Role of Adrenal Medulla and Renin-Angiotensin System in Sympathetic Neurotransmission in Spontaneously Hypertensive and Normotensive Rats
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Kim In-Kyeom
Kim Choong-Young
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Abstract
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To assess the role of adrenal medulla and renin-angiotensin system in the regulation of sympathetic neurotransmission, the pressor response to PNS was evaluated in pithed SHR and normotensive WKY or SDR with or without adrenal demedullation and/or enalapril pretreatment. Three weeks after adrenal demedullation, MAP and the heart rate of demedullated rats were similar to their corresponding sham-operated groups. The pressor response to PNS was frequency-dependent, and blocked by prazosin. In contrast to the normotensive rats, in SHR, the pressor response to PNS was attenuated in demedullated rats as compared with sham-operated rats. However, the attenuation of PNS-induced pressor responses in demedullated SHR was not observed in enalapril-treated SHR. The adrenal demedullation in SHR did not affect the plasma and aortic catecholamine contents in spite of the decreased catecholamine contents of adrenal gland, nor ACE activity in aortic strips. But, in WKY rats, the aortic catecholamines, especially epinephrine, contents as well as ACE activity were increased by adrenal demedullation. These results suggest that the facilitatory role of adrenal medulla in sympathetic neurotransmission depends upon the activation of renin-angiotensin system, and that the compensatory regulation of renin-angiotensin system takes place in normotensive rats but not in SHR.
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KEYWORD
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Adrenal Demedullation, Renin-Angiotensin System, Catecholamines, Sympathetic Neurotransmission, Spontaneously Hypertensive Rats
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